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Updated: Aug 18, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
Published on: May 16, 2020
Pathology of radiation and anthracycline cardiotoxicity
Gerald J Berry1, Michelle Jorden
1Division of Cardiac Pathology, Department of Pathology, Stanford University Medical Center, Stanford California 94305, USA. gjberry@stanford.edu
Abstract:
Radiation-induced heart disease (RIHD) and anthracycline cardiotoxicity are two patterns of cardiac dysfunction caused by therapeutic interventions to treat malignancies. They occur in both the pediatric and adult populations and there is evidence to suggest that pediatric patients are at greater risk. This is due in part to the longer survival rates but also reflects increased susceptibility to the attendant complications caused by both therapies. Radiation can cause injury to all the components of the heart, including the vasculature, while anthracycline toxicity is generally limited to the myocardium.
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