Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Persistent oligoclonal CD4dimCD8+T cells in peripheral blood.

Claude Lambert1, Cristina Iobagiu, Christian Genin

  • 1Immunology Laboratory, University Hospital of St. Etienne, St. Etienne, France. claude.lambert@univ-st-etienne.fr

Cytometry. Part B, Clinical Cytometry
|April 13, 2005
PubMed
Summary

Researchers identified CD4dimCD8+ T cells, finding they often express a single T-cell receptor Vbeta clonotype. This suggests a potential oligoclonal reaction or an emerging lymphoproliferative disorder needing further study.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A multiparametric 3D cortical neurosphere NAM for developmental neurotoxicity: Chlorpyrifos and a biomonitoring-anchored PFAS mixture.

Neurotoxicology·2026
Same author

Evaluation of Cell Mimics as Potential Quality Controls for Human Leukocyte Immunophenotyping.

Medical sciences (Basel, Switzerland)·2025
Same author

Epigenetic and Genotoxic Mechanisms of PFAS-Induced Neurotoxicity: A Molecular and Transgenerational Perspective.

Toxics·2025
Same author

Diagnosis of propofol allergy (the innovative role of the basophil activation test in the identification of allergen): a case report.

The Pan African medical journal·2025
Same author

Drug hypersensitivity to vancomycin confirmed by basophil activation test: case report.

The Pan African medical journal·2025
Same author

Effects of isolated, confined and extreme environments on parameters of the immune system - a systematic review.

Frontiers in immunology·2025

Area of Science:

  • Immunology
  • Cell Biology
  • T-cell Phenotyping

Background:

  • Routine CD4/CD8 T-cell phenotyping can reveal a small fraction of CD4dimCD8+ T cells.
  • These cells exhibit a homogeneous appearance, similar to observations in lymphoproliferative syndromes or chronic infections.

Purpose of the Study:

  • To investigate the significance and diversity of CD4dimCD8+ T cells.
  • To determine if these cells represent a specific immune response or a pathological condition.

Main Methods:

  • Phenotyping was conducted on 272 samples from healthy, elderly, and immunocompromised individuals (HIV, renal transplant).
  • Analysis included CD4/CD8 T-cell expression, activation markers (CD69), and T-cell receptor Vbeta repertoire.

Main Results:

Related Experiment Videos

  • CD4dimCD8+ T cells showed decreased CD4 fluorescence intensity but normal CD8 levels.
  • Frequencies in HIV and renal transplant patients were not significantly different from healthy donors.
  • A predominant T-cell receptor Vbeta clonotype was identified in 13 of 26 samples, indicating potential clonality.

Conclusions:

  • The findings suggest an oligoclonal reaction to chronic inflammation or an emerging lymphoproliferative disorder.
  • The phenomenon is proposed to be named "oligoclonal clonopathy of undetermined significance" pending longitudinal studies.