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Indocyanine Green-Guided Intraoperative Imaging to Facilitate Video-Assisted Retroperitoneal Debridement for Treating Acute Necrotizing Pancreatitis
04:01

Indocyanine Green-Guided Intraoperative Imaging to Facilitate Video-Assisted Retroperitoneal Debridement for Treating Acute Necrotizing Pancreatitis

Published on: September 8, 2022

[Fungal infections in patients with necrotizing pancreatitis: risk-factors, incidence, therapy]

P Kujath1, M Rosenfeldt, H Esnaashari

  • 1Klinik für Chirurgie, Universitätsklinikum Schleswig-Holstein, D-23538 Lübeck, Germany. kujath-luebeck@t-online.de

Mycoses
|April 14, 2005
PubMed

Insights

Fungal infections are common in patients with severe necrotizing pancreatitis requiring surgery. This study found a high incidence of fungal infections and a significant mortality rate in these critically ill patients.

Area of Science:

  • Medicine
  • Infectious Diseases
  • Gastroenterology

Background:

  • Hemorrhagic necrotizing pancreatitis is a severe condition often leading to multi-organ failure and requiring intensive care.
  • Surgical intervention (necrosectomy) is common for infected necrosis, allowing for microbiological analysis.
  • Enterobacteriaceae are the most frequent bacterial pathogens, while fungal infections are reported in 15-30% of cases.

Purpose of the Study:

  • To investigate the incidence and outcomes of fungal infections in patients undergoing surgical treatment for necrotizing pancreatitis.

Main Methods:

  • Retrospective analysis of 73 patients surgically treated for necrotizing pancreatitis between 1996 and the present.
  • Microbiological analysis of surgical specimens to identify fungal pathogens.
  • Evaluation of patient outcomes, including mortality rates.

Main Results:

  • A high incidence of fungal infections was observed, affecting 68.5% (50 out of 73) of surgically treated patients.
  • The overall mortality rate in this cohort was 62%.
  • Enterobacteriaceae were the most common bacterial species identified.

Conclusions:

  • Fungal infections are highly prevalent in patients with surgically treated necrotizing pancreatitis, significantly exceeding previously reported rates.
  • The high mortality rate underscores the severity of this complication and the need for effective management strategies.
  • Further research is warranted to understand the mechanisms and optimize treatment for fungal infections in this patient population.

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