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Updated: Aug 18, 2026

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
[Surgical treatment of pulmonary aspergilloma]
T Schulte1, K Welcker, J Schatz
1Klinik für Chirurgie, Universitätsklinikum Schleswig-Holstein, Lübeck, Germany.
Abstract:
Invasive pulmonary aspergillosis is a life-threatening disease, developing from infection mostly by Aspergillus fumigatus. It is an opportunistic infection and occurs mostly in immunosuppressed patients, after tuberculosis, in patients with AIDS or malignomas. The most common symptom and complication is hemoptysis up to massive bleeding. Surgical treatment is obligatory on patients with a pulmonary aspergilloma. Time and form of intervention should be discussed between surgeon and pulmonologist. Resection should follow anatomical borders like lobectomy or pneumectomy. Any remaining intrathoracic cavities should be filled either with remaining lung tissue or with muscle flaps of latissimus or pectoralis muscle or omentum majus. Following these rules, intervention can be performed with reasonable mortality and morbidity rate.
Insights
Invasive pulmonary aspergillosis, often caused by Aspergillus fumigatus, is a severe infection primarily affecting immunocompromised individuals. Surgical resection following anatomical borders offers a viable treatment option with acceptable outcomes.
Area of Science:
- Pulmonology
- Infectious Diseases
- Surgical Oncology
Background:
- Invasive pulmonary aspergillosis is a life-threatening opportunistic infection.
- It predominantly affects immunocompromised patients, including those with AIDS or malignomas, and can follow tuberculosis.
- Hemoptysis, ranging from mild to massive bleeding, is a common symptom and complication.
Purpose of the Study:
- To outline the indications and surgical management of pulmonary aspergilloma.
- To emphasize the importance of multidisciplinary discussion between surgeons and pulmonologists for optimal timing and approach.
- To detail the surgical techniques for resection and management of residual cavities.
Main Methods:
- Surgical resection of pulmonary aspergilloma is indicated.
- Resection should adhere to anatomical planes, such as lobectomy or pneumectomy.
- Intrathoracic cavities require obliteration using lung tissue, muscle flaps (latissimus, pectoralis), or omentum majus.
Main Results:
- Surgical intervention, when following established guidelines, can be performed with reasonable mortality and morbidity.
- Adherence to anatomical resection and cavity obliteration techniques is crucial for successful outcomes.
- Multidisciplinary collaboration ensures appropriate patient selection and management strategy.
Conclusions:
- Surgical management is obligatory for pulmonary aspergilloma.
- Careful planning and execution of resection and cavity management are key to minimizing complications.
- This approach allows for effective treatment of invasive pulmonary aspergillosis with acceptable patient outcomes.
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