Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bipolar disorder and substance abuse.

E Sherwood Brown1

  • 1Psychoneuroendocrine Research Program, Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. sherwood.brown@utsouthwestern.edu

The Psychiatric Clinics of North America
|April 14, 2005
PubMed
Summary

Substance use disorders (SUDs) frequently co-occur with Borderline Personality Disorder (BPD). Effective mood stabilizers may reduce substance use in individuals with both conditions, though more research is needed.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of cognitive impairment and depression on asthma in older patients.

The journal of allergy and clinical immunology. In practice·2026
Same author

The association between alcohol consumption and inflammatory biomarkers in a large, diverse, community-based sample.

Alcohol and alcoholism (Oxford, Oxfordshire)·2026
Same author

Highlights for the <i>Journal of Dual Diagnosis</i> from 2025.

Journal of dual diagnosis·2025
Same author

Toward the 2025 ACLP Annual Meeting: Advancing Consultation-Liaison Psychiatry Through Inspiration, Investigation, Innovation, and Implementation.

Journal of the Academy of Consultation-Liaison Psychiatry·2025
Same author

Correction: Evaluating psychiatry journals' adherence to informed consent guidelines for case reports.

Research integrity and peer review·2025
Same author

Evaluating psychiatry journals' adherence to informed consent guidelines for case reports.

Research integrity and peer review·2025

Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Addiction Medicine

Background:

  • Substance use disorders (SUDs) are highly prevalent among individuals diagnosed with Borderline Personality Disorder (BPD).
  • The etiological underpinnings of the comorbidity between SUDs and BPD remain incompletely elucidated, potentially involving shared genetic vulnerabilities, neurobiological factors, and psychological mechanisms.
  • The presence of SUDs in patients with BPD is frequently linked to poorer clinical outcomes and a more complicated disease trajectory.

Purpose of the Study:

  • To explore the complex relationship between SUDs and BPD.
  • To review the limited existing research on the treatment of comorbid BPD and SUDs.
  • To investigate potential therapeutic avenues, particularly the role of mood-stabilizing medications.

Main Methods:

Related Experiment Videos

  • This review synthesizes findings from existing literature on the comorbidity of SUDs and BPD.
  • Analysis of reported treatment outcomes for patients with co-occurring BPD and SUDs.
  • Examination of preliminary data on the efficacy of specific pharmacological interventions.

Main Results:

  • SUDs are a common and significant clinical issue in the BPD population.
  • Comorbid SUDs in BPD are associated with a worse prognosis.
  • Initial reports suggest that mood-stabilizing medications may have a beneficial effect on reducing substance use in this population.

Conclusions:

  • The co-occurrence of SUDs and BPD presents significant challenges in treatment and prognosis.
  • Further research is critically needed to understand the mechanisms driving this comorbidity and to develop effective, evidence-based treatment strategies.
  • Mood stabilizers show promise as a potential treatment component for managing SUDs in individuals with BPD, warranting further investigation.