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Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
Published on: August 13, 2013
T cell homeostasis: keeping useful T cells alive and live T cells useful
1Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, MN, USA. james024@umn.edu
Abstract:
It has become clear that the regulation of T cell numbers is under peripheral homeostatic control. However, the rules for homeostasis vary with the T cells' differentiation state and the overall T cell number in the animal. Furthermore, homeostatic pressures can cause unexpected changes in T cell differentiation and function which might promote or dampen T cell reactivity. In this review, we focus on the role of peptide/MHC and cytokine interactions in regulating the size and composition of the T cell pool.
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