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Comparative effects of tetrandrine and berbamine on acute and relapsing experimental allergic encephalitis in Lewis
C W Wong1, W K Seow, Y H Thong
1Department of Child Health, University of Queensland, Mater Childrens Hospital, South Brisbane, Australia.
International Archives of Allergy and Immunology
|January 1, 1992
Abstract:
The effects of the bisbenzylisoquinoline alkaloids tetrandrine and berbamine on experimental allergic encephalitis (EAE) in Lewis rats was investigated. Amelioration of the acute-phase EAE was only minimal. However, the incidence of relapsing EAE was reduced by 41 and 65% for tetrandrine and berbamine, respectively, at the non-toxic treatment schedule of 60 mg/kg administered on alternate days. These results suggest that bisbenzylisoquinoline compounds may have a potential role in the therapy of progressive multiple sclerosis.