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Related Experiment Videos

Inhaled insulin: Exubera.

Peggy Soule Odegard1, Kam L Capoccia

  • 1School of Pharmacy, University of Washington, Seattle, WA 98195-7630, USA. podegard@u.washington.edu

The Annals of Pharmacotherapy
|April 14, 2005
PubMed
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Exubera, an inhaled insulin, offers effective premeal treatment for type 1 and type 2 diabetes, showing improved patient satisfaction compared to injections. Further studies are needed to fully evaluate its use with newer insulin analogs.

Area of Science:

  • Pharmacology and Therapeutics
  • Endocrinology
  • Respiratory Medicine

Background:

  • Exubera is a novel, dry-powder formulation of insulin for inhalation.
  • It is designed for preprandial administration to manage type 1 and type 2 diabetes mellitus.

Purpose of the Study:

  • To review the pharmacology, pharmacokinetics, efficacy, and safety of inhaled Exubera.
  • To describe patient satisfaction and quality-of-life data associated with Exubera use.

Main Methods:

  • A comprehensive literature search was conducted using MEDLINE, BIOSIS Previews, and American Diabetes Association Scientific Abstracts.
  • Human studies of Exubera were selected for review, with additional citations identified from reference lists.

Main Results:

Related Experiment Videos

  • Exubera demonstrated similar efficacy to standard subcutaneous insulin therapy and improved patient satisfaction.
  • Its onset of action is rapid, similar to regular insulin, and it has shown efficacy as adjunctive therapy for type 2 diabetes.
  • Pulmonary safety appears maintained up to 4 years, but data in patients with pulmonary conditions are lacking.

Conclusions:

  • Exubera is an effective inhaled insulin for preprandial use in both type 1 and type 2 diabetes.
  • Improved patient satisfaction suggests potential for earlier use in type 2 diabetes management compared to injected insulin.