Optimization of "Askoeziuofito" tablets

Area of Science:

• Pharmaceutical Technology
• Materials Science

Background:

• Tablet formulation requires careful selection of excipients to achieve desired technological properties.
• Optimizing excipient levels is crucial for tablet quality, including mechanical strength and drug release.

Purpose of the Study:

• To experimentally determine optimal limits for excipients (silica colloidal anhydrous, magnesium stearate, potato starch, saccharose).
• To evaluate the impact of these excipients on tablet sticking, crushing strength, abrasion resistance, and drug release speed.

Main Methods:

• Technological parameters assessed: mean mass, crushing strength, abrasion resistance, disintegration time, and release rate of ascorbic and chicoric acids.
• Active substances identified and quantified using chromatography (HPLC, TLC) and spectrophotometry.
• Mathematical planning techniques (fractional factorial design, steepest ascent, orthogonal compositional design) employed for optimization.

Main Results:

• Optimal excipient amounts were identified using mathematical planning.
• These optimized formulations resulted in improved tablet crushing strength, abrasion resistance, and controlled drug release.
• Developed and validated analytical methods for active substances in tablets and performed stability tests.

Conclusions:

• Mathematical planning is effective for optimizing tablet formulations.
• Optimized excipient levels ensure desired tablet quality attributes and predictable drug release profiles.
• Established analytical and stability testing protocols for pharmaceutical preparations.