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Updated: Aug 18, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Polycyclic compounds from aminopolyols and alpha-dicarbonyls: structure and application in the synthesis of
Giovanni B Giovenzana1, Giovanni Palmisano, Erika Del Grosso
1Dipartimento di Scienze Chimiche Alimentari Farmaceutiche Farmacologiche, Novara, Italy. giovenza@pharm.unipmn.it
Abstract:
The structure and stereochemistry of the crystalline 2 : 2 condensation product ("glytham") of glyoxal and tris(hydroxymethyl)aminomethane was conclusively determined by X-ray diffractometric analysis. The singular disposition of the heteroatoms suggests the employment of glytham as starting material for the synthesis of ditopic ligands for metal ions. Some derivatives of glytham were prepared and their binding properties towards alkaline metal ions were preliminarily investigated by ESI-MS and NMR.
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