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Related Experiment Videos

Human optic nerve fiber count and optic disc size.

J B Jonas1, A M Schmidt, J A Müller-Bergh

  • 1Department of Ophthalmology, University Erlangen-Nürnberg, FRG.

Investigative Ophthalmology & Visual Science
|May 1, 1992
PubMed
Summary

Eyes with larger optic discs have more optic nerve fibers, suggesting greater anatomical reserve capacity. Optic nerve fiber count declines with age, impacting optic neuropathies like glaucoma.

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Histology

Background:

  • The optic nerve head's neuroretinal rim represents optic nerve fibers.
  • Rim area and optic disc size show high interindividual variability.
  • Previous studies noted a correlation between rim area and optic disc size.

Purpose of the Study:

  • To investigate if larger optic discs correlate with a higher optic nerve fiber count.
  • To determine the relationship between optic disc size and optic nerve fiber quantity.
  • To assess the impact of age on optic nerve fiber count.

Main Methods:

  • Histomorphometric evaluation of 72 optic nerves from 56 cornea donors.
  • Utilized computerized image analysis for semithin sections.
  • Quantified optic nerve fiber count and related it to optic disc size and age.

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Main Results:

  • Optic nerve fiber count significantly increased with larger optic disc size (P=0.01).
  • Nerve fiber count positively correlated with retrobulbar optic nerve cross-section area.
  • Fiber count decreased with age (approx. 4,000 fibers/year); density decreased with larger discs.

Conclusions:

  • Larger optic discs are associated with higher optic nerve fiber counts and greater anatomical reserve capacity.
  • Age-related decline in optic nerve fibers impacts optic neuropathies.
  • Optic nerve fiber crowding is more pronounced in smaller optic discs, potentially exacerbating age-related fiber loss in conditions like glaucoma.