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Related Experiment Videos

[PPARs-mediated intracellular signal transduction].

Hiroshi Fujii1

  • 1Division of Molecular and Cellular Biology, Department of Signal Transduction Research, Niigata University, Graduate School of Medical and Dental Sciences.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|April 15, 2005
PubMed
Summary
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Peroxisome proliferator-activated receptors (PPARs) are crucial nuclear receptors regulating metabolism. This review highlights emerging knowledge on PPARs

Area of Science:

  • Molecular biology
  • Endocrinology
  • Metabolism

Context:

  • Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors activated by fatty acids and their derivatives.
  • PPARs comprise three isotypes: PPARalpha (NR1C1), PPARbeta/delta (NR1C2), and PPARgamma (NR1C3), each encoded by a separate gene.
  • These receptors bind fatty acids and eicosanoids, playing vital roles in cellular processes.

Purpose:

  • To review emerging knowledge on the roles of PPARs in various intracellular signaling pathways.
  • To elucidate the diverse functions of PPAR isotypes beyond their established roles in metabolic regulation.

Summary:

  • PPARs are key regulators of lipid, carbohydrate, and amino acid metabolism, acting as essential fatty acid sensors.
  • Beyond metabolism, PPARs significantly influence crucial signaling pathways involved in immunity, inflammation, apoptosis, and cell differentiation.

Related Experiment Videos

  • This review focuses on the expanding understanding of PPARs' involvement in intracellular signaling.

    • Impact:

    • Provides a comprehensive overview of PPARs' multifaceted roles in cellular signaling.
    • Highlights the therapeutic potential of targeting PPARs for various physiological and pathological conditions.
    • Advances the understanding of nuclear receptor function in complex biological systems.