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[PPARs target genes]

Ichiro Takada1, Shigeaki Kato

  • 1Nuclear Signaling, Institute of Molecular and Cellular Biosciences, University of Tokyo.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|April 15, 2005
PubMed

Insights

Peroxisome proliferator-activated receptors (PPARs) regulate key cellular processes and are linked to metabolic diseases. This review summarizes PPAR target genes involved in lipid metabolism and adipocyte differentiation.

Area of Science:

  • Molecular biology
  • Endocrinology
  • Metabolic research

Context:

  • Peroxisome proliferator-activated receptors (PPARs) are crucial nuclear receptors involved in maintaining metabolic homeostasis.
  • PPARs (alpha, beta/delta, gamma) regulate gene expression through heterodimerization with retinoid X receptors (RXRs).
  • Dysregulation of PPARs is associated with metabolic disorders like obesity, diabetes, and atherosclerosis.

Purpose:

  • To provide a comprehensive summary of known PPAR direct and indirect target genes.
  • To elucidate the functions of these target genes, particularly in relation to lipid metabolism and adipocyte differentiation.
  • To consolidate current knowledge on PPAR-mediated gene regulation in metabolic health.

Summary:

  • PPARs, in complex with RXRs, bind specific DNA response elements to modulate gene transcription.
  • Numerous direct and indirect target genes of PPARs have been identified.
  • These genes play critical roles in lipid metabolism, including fatty acid oxidation and triglyceride synthesis, and are fundamental to adipocyte differentiation processes.

Impact:

  • This review offers a valuable resource for researchers studying PPARs and metabolic diseases.
  • Understanding PPAR target genes enhances insights into the molecular mechanisms underlying lipid disorders and obesity.
  • The information can guide the development of novel therapeutic strategies targeting PPARs for metabolic diseases.

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