Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

[Polymorphisms of PPARs and metabolic disorders].

Eiichi Araki¹, Motoyuki Igata, Hiroyuki Motoshima

¹Department of Metabolic Medicine, Graduate School of Medical Sciences, Kumamoto University.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|April 15, 2005

Summary

Peroxisome proliferator-activated receptors (PPARs) regulate glucose and lipid metabolism. The PPARgamma Pro12Ala gene variant is linked to improved insulin sensitivity and a lower risk of developing diabetes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Impact of Endothelium-Derived Mitochondrial Reactive Oxygen Species on Obesity-Associated Atherosclerosis.

Antioxidants & redox signaling·2026

Same author

Heat shock protein 72 (HSP72) modulates glucagon secretion via JNK inhibition in pancreatic α-cells.

Diabetology international·2026

Same author

Efficacy for LDL-C-lowering and safety of pemafibrate extended-release formulation in patients with statin-intolerant hypercholesterolemia: A phase 3 multicenter, randomized, double-blind, placebo-controlled, parallel-group trial.

Journal of clinical lipidology·2026

Same author

Hematopoietic dipeptidyl peptidase-4 deficiency promotes M2 macrophage polarization and attenuates atherosclerosis.

Biochemical and biophysical research communications·2025

Same author

Histopathological evaluation of dopamine receptor D2 expression in symptomatic gonadotroph pituitary neuroendocrine tumors: a case series including a rare metastatic case responsive to a dopamine agonist.

Brain tumor pathology·2025

Same author

Editorial: Recent advances in secondary diabetes and glucose intolerance.

Frontiers in endocrinology·2025

Area of Science:

Molecular biology
Genetics
Metabolic disorders

Context:

Peroxisome proliferator-activated receptors (PPARs) are crucial transcriptional factors regulating glucose and lipid metabolism.
Gene polymorphisms in PPARs have been investigated for their association with metabolic disorders.
The Pro12Ala polymorphism in the PPARgamma gene is extensively studied.

Purpose:

To examine the impact of PPARs gene polymorphisms on metabolic disorders.
To investigate the role of the PPARgamma Pro12Ala polymorphism in metabolic health.
To explore potential therapeutic strategies for metabolic disorders based on PPARs function.

Summary:

The Pro12Ala polymorphism of the PPARgamma gene is associated with enhanced insulin sensitivity.

Related Experiment Videos

This specific gene variant is linked to a reduced risk of developing diabetes.

Understanding PPARs' role is key to elucidating metabolic disorder development.

Impact:

Provides insights into the genetic basis of metabolic regulation.
Highlights the potential of PPARs as therapeutic targets for diabetes and metabolic diseases.
Contributes to the development of personalized medicine approaches for metabolic disorders.