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Related Concept Videos

Rheumatic Heart Disease IV: Nursing Management01:20

Rheumatic Heart Disease IV: Nursing Management

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AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
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Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

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Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
508
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

452
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Implantation of Total Artificial Heart in Congenital Heart Disease07:27

Implantation of Total Artificial Heart in Congenital Heart Disease

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This is a case report of a patient with congenitally corrected transposition of the great arteries (CCTGA) who received a total artificial heart (TAH) as a bridge to heart transplant. The TAH was successfully implanted with modifications to accommodate the patient's congenitally malformed...
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Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

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Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
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Related Experiment Video

Updated: Jan 19, 2026

Dissection Techniques and Histological Sampling of the Heart in Large Animal Models for Cardiovascular Diseases
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[PPARs and heart diseases].

Hiroyuki Takano1, Issei Komuro

  • 1Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|April 15, 2005
PubMed
Summary

Peroxisome proliferator-activated receptors (PPARs) show potential in treating cardiovascular diseases. Their ligands regulate metabolism and exhibit broader therapeutic effects beyond glucose and lipid control.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Context:

  • Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors involved in metabolic regulation.
  • Activation of PPARalpha and PPARgamma is known to suppress proinflammatory cytokine production.
  • Research interest in PPARs has surged due to their multifaceted roles.

Purpose:

  • To review the latest developments in PPAR research.
  • To explore the role of PPAR-dependent pathways in cardiovascular diseases.
  • To highlight the potential of PPAR ligands as therapeutic agents.

Summary:

  • PPAR ligands, including thiazolidinediones (TZDs) for PPARgamma and fibrates for PPARalpha, regulate glucose and lipid metabolism.
  • Emerging research indicates that PPAR ligands possess pleiotropic effects across various tissues and cell types.

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  • This review focuses on recent advancements and the implications of PPAR pathways in cardiovascular health.

    • Impact:

    • PPAR ligands may offer novel therapeutic strategies for cardiovascular disease prevention.
    • Understanding PPAR pathways can lead to treatments that address metabolic disorders and inflammation.
    • The pleiotropic effects of PPARs suggest broad applications in managing complex diseases.