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Updated: Aug 18, 2026
Dynamic Assessments of Coronary Flow Reserve after Myocardial Ischemia Reperfusion in Mice
Published on: August 25, 2023
Characteristic changes in cerebral perfusion during on-pump and off-pump coronary artery surgery
Tetsuya Ueno1, Kazuyuki Ikeda, Shigefumi Matsuyama
1Division of Cardiovascular Surgery, Ureshino Medical Center, Ureshino-machi, Saga, Japan.
Objective:
We investigated the cerebral perfusion status during on-pump or off-pump coronary artery bypass grafting (CABG).
Methods:
We monitored somatosensory evoked potential (SEP) and regional cerebral oxygen saturation (rSO2) as parameters of cerebral perfusion in an on-pump group (n=10) and an off-pump group (n=16). The percent changes from control values were calculated before, during, and after aortic clamping, and after weaning from cardiopulmonary bypass, in the on-pump group. In the off-pump group, these were calculated before, during, and after heart displacement for distal anastomosis.
Results:
In the on-pump group, the amplitudes of the SEP were significantly enhanced during and after aortic cross-clamping and were associated with a significant decrease in rSO2. Latency was prolonged immediately after aortic cross-clamping, but was shortened afterwards. There was little change in these parameters throughout the operation, in the off-pump group.
Conclusions:
Cerebral perfusion remains stable during off-pump CABG. The etiology of a simultaneous increase in SEP amplitude and decrease in rSO2 during the rewarming period in the on-pump group requires further investigation.
