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[Resorbable pericardial replacement--an experimental study].

A Liermann1, M Lachat, L K von Segesser

  • 1Klinik für Herz- und Gefässchirurgie, Universitätsspital Zürich.

Helvetica Chirurgica Acta
|January 1, 1992
PubMed
Summary
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Vicryl-Collagen mesh shows promise as a resorbable pericardial substitute in heart surgery. This material resulted in minimal adhesions and effective pericardial defect closure in a rat study, suggesting superior performance over Gore-Tex.

Area of Science:

  • Biomaterials Science
  • Cardiovascular Surgery
  • Regenerative Medicine

Background:

  • Cardiac surgery patients often require reoperation, necessitating pericardial closure.
  • Current pericardial substitutes lack ideal properties, posing risks during resternotomy.
  • Developing effective resorbable pericardial substitutes is crucial for patient safety.

Purpose of the Study:

  • To evaluate Gore-Tex Surgical Membrane and Vicryl-Collagen mesh as resorbable pericardial substitutes.
  • To assess the biocompatibility and efficacy of these materials in a preclinical model.
  • To determine the potential for neopericardium formation.

Main Methods:

  • Orthotopic implantation of Gore-Tex and Vicryl-Collagen mesh in 12 rats.
  • Macroscopic evaluation of pericardial adhesions and defect closure after 86 days.

Related Experiment Videos

  • Histological analysis of inflammatory response and tissue integration.

    • Main Results:

    • Both substitutes demonstrated low levels of pericardial adhesion.
    • Vicryl-Collagen mesh exhibited minimal inflammatory cell infiltration.
    • Complete closure of the pericardial defect occurred in 4 out of 6 rats receiving Vicryl-Collagen mesh.

    Conclusions:

    • Vicryl-Collagen mesh appears to be a superior resorbable pericardial substitute compared to Gore-Tex.
    • This material facilitates effective pericardial defect closure and promotes neopericardium formation.
    • Further research is warranted to explore its clinical application in cardiac surgery.