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Related Experiment Videos

The BAFF/APRIL system: life beyond B lymphocytes.

Lai Guan Ng1, Charles R Mackay, Fabienne Mackay

  • 1Arthritis and Asthma Research Program, The Garvan Institute of Medical Reseach, 384 Victoria St, Sydney, NSW 2010, Australia.

Molecular Immunology
|April 15, 2005
PubMed
Summary

Targeting B cell activating factor (BAFF) and proliferation-inducing ligand (APRIL) may treat autoimmune diseases and lymphoid cancers. Inhibiting these TNF superfamily members impacts pathogenic B and T cell functions, crucial for disease progression.

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Area of Science:

  • Immunology
  • Molecular Biology
  • Oncology

Background:

  • B cell activating factor (BAFF) and proliferation-inducing ligand (APRIL) are TNF superfamily members regulating B cell homeostasis, tolerance, and malignancy.
  • The BAFF/APRIL system is critical for B cell survival, influencing autoimmune diseases and lymphoid cancers.

Purpose of the Study:

  • To investigate the therapeutic potential of targeting the BAFF/APRIL system.
  • To explore the role of BAFF in T cell activation and differentiation in autoimmune diseases.

Main Methods:

  • Studies involving animal models of autoimmunity.
  • Analysis of BAFF inhibitors' effects on B cell survival and lymphoid cancer cells.
  • Investigation of BAFF's role in T cell activation and differentiation.

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Main Results:

  • Neutralizing BAFF inhibited disease progression in animal models of autoimmunity by reducing autoreactive B cell survival.
  • BAFF inhibitors demonstrated efficacy in preventing B lymphoma cell survival, suggesting potential for lymphoid cancer treatment.
  • Emerging evidence indicates BAFF's importance in T cell activation and differentiation, relevant to autoimmune disease progression.

Conclusions:

  • Targeting the BAFF/APRIL system offers a promising therapeutic strategy for autoimmune diseases and lymphoid cancers.
  • Inhibiting BAFF and APRIL can modulate pathogenic B and T cell functions, providing a dual benefit for treating these conditions.