Related Experiment Videos
Recurrent Alcaligenes xylosoxidans keratitis
Zei-Lun Huang1, Yeong-Fong Chen, Shu-Wen Chang
1Department of Ophthalmology, Chang Gung Memorial Hospital, Taipei, Taiwan, Republic of China.
Cornea
|April 15, 2005
Summary
Recurrent Alcaligenes xylosoxidans keratitis after corneal transplant is challenging to treat. This case highlights the need for therapeutic penetrating keratoplasty when medical therapy fails for this rare ocular infection.
Area of Science:
- Ophthalmology
- Microbiology
- Infectious Diseases
Background:
- Postkeratoplasty infections can lead to graft failure.
- Alcaligenes xylosoxidans is an opportunistic pathogen rarely implicated in ocular infections.
Observation:
- A 33-year-old male presented with recurrent keratitis following penetrating keratoplasty.
- Corneal infiltrate with intact epithelium was observed.
- Cultures identified Alcaligenes xylosoxidans, initially sensitive to piperacillin and ceftazidime.
Findings:
- The patient experienced three recurrent episodes of keratitis despite topical antibiotic treatment.
- The infection became recalcitrant to both piperacillin and ceftazidime.
- Therapeutic penetrating keratoplasty was ultimately required for infection eradication.
Implications:
- Alcaligenes xylosoxidans may be an underreported cause of postkeratoplasty infectious keratitis.
- This pathogen can exhibit resistance to conventional antibiotic regimens.
- Therapeutic penetrating keratoplasty is a viable option for recalcitrant cases unresponsive to medical management.