Related Experiment Video
Updated: Jul 31, 2026
10:18
From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
Published on: October 19, 2014
Langerhans-cell histiocytosis: a clinical case without bone involvement
M Manfredi1, D Corradi, P Vescovi
1Department of Otorhino-Laryngology and Ophthalmology, Dental and Maxillo-Facial Sciences, Dentistry and Oral Medicine Section, University of Parma, Parma, Italy. maddalena.manfredi@unipr.it
Journal of Periodontology
|April 16, 2005
Summary
Oral soft tissue lesions can be an early sign of Langerhans-cell histiocytosis (LCH). Periodontists play a key role in detecting this rare disease, even without bone involvement.
Area of Science:
- Oral pathology
- Dermatology
- Oncology
Background:
- Langerhans-cell histiocytosis (LCH) is a rare neoplastic disorder characterized by Langerhans cell proliferation.
- LCH can affect multiple organ systems, with bone, lung, liver, and skin commonly involved.
- Oral soft tissue lesions without bone involvement are infrequent presentations of LCH.
Observation:
- A case study of a 23-year-old male patient presenting with LCH.
- The patient exhibited concurrent oral soft tissue, cutaneous, and pulmonary lesions.
- Diagnosis was established through oral lesion biopsy, leading to comprehensive disease staging.
Findings:
- Oral lesions, specifically gingival, can serve as an initial clinical manifestation of LCH.
- Early detection through oral examination is crucial for timely diagnosis and management.
- The case highlights the importance of considering LCH in the differential diagnosis of oral lesions.
Implications:
- Periodontists and dentists are vital in identifying early signs of LCH.
- Prompt recognition of oral manifestations can lead to earlier staging and treatment initiation.
- This case underscores the need for interdisciplinary collaboration in managing rare diseases like LCH.
