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Updated: Aug 18, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
Published on: March 14, 2025
The frontal lobes and the regulation of mental activity
Sharon L Thompson-Schill1, Marina Bedny, Robert F Goldberg
1Department of Psychology, Center for Cognitive Neuroscience, University of Pennsylvania, Philadelphia, PA 19104-6241, USA. thompson@psych.upenn.edu
Abstract:
Results of neuroimaging and neuropsychological studies of frontal lobe function have been interpreted by some as evidence for specialized modules that are localized to distinct regions of frontal cortex, and that differ in both content and process from those in neighboring regions. These descriptions stand in stark contrast to the many domain-general theoretical accounts of the regulatory role of the frontal lobes in cognition. Recent attempts to understand how general regulatory mechanisms might operate across multiple domains (e.g. working memory, sentence comprehension) have been increasingly important in our understanding of the frontal lobes.
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