Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hereditary multiple exostosis and pain.

Sandra Darilek1, Catherine Wicklund, Diane Novy

  • 1Department of Pediatrics, University of Texas-Houston Medical School, Houston, TX 77225, USA.

Journal of Pediatric Orthopedics
|April 16, 2005
PubMed
Summary

Pain is a significant issue for individuals with hereditary multiple exostosis (HME), affecting 84% of patients. HME complications and surgery increase pain likelihood, underscoring the need for better pain management in HME care.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ceftaroline pharmacokinetics on ECMO, a pediatric case report.

International journal of antimicrobial agents·2026
Same author

Apolipoprotein L1 Genetic Testing and Counseling Does Not Reduce Living Kidney Donors' Willingness to Donate : A Hybrid Type 2 Nonrandomized Controlled Trial.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same author

Impact of Sinus Surgery on Bacteriome Composition in Patients With Chronic Rhinosinusitis With Nasal Polyps.

International forum of allergy & rhinology·2025
Same author

Two commonly reported incidental variants in OTC are associated with late-onset disease.

HGG advances·2025
Same author

Development and Evaluation of a Culturally Targeted <i>Apolipoprotein L1</i> Counseling Training Program for Transplant Clinicians: A Pilot Study.

Kidney medicine·2025
Same author

An Overview of Listeriosis Outbreak Investigations in the United States Linked to Imported Enoki Mushrooms and Associated Regulatory Activities, Research, and Food Safety Knowledge Gaps.

Comprehensive reviews in food science and food safety·2025

Area of Science:

  • Medical research
  • Genetics
  • Pain management

Background:

  • Hereditary multiple exostosis (HME) is a genetic disorder characterized by the growth of multiple benign tumors (exostoses).
  • The prevalence and impact of pain in HME patients are not fully understood.
  • Previous research has underestimated the extent of pain experienced by individuals with HME.

Purpose of the Study:

  • To characterize the prevalence and nature of pain in individuals diagnosed with hereditary multiple exostosis (HME).
  • To identify factors associated with pain in the HME population.
  • To assess the impact of pain on the quality of life for HME patients.

Main Methods:

  • A questionnaire was administered to 293 patients diagnosed with HME.
  • The questionnaire assessed pain experience, pain distribution (generalized vs. localized), and its impact on daily life.

Related Experiment Videos

  • Statistical analysis was performed to identify correlations between pain and factors such as HME-related complications and surgical history.

    • Main Results:

    • A high prevalence of pain was reported, with 84% of HME patients experiencing pain.
    • Generalized pain was reported by 55.1% of those with pain.
    • HME-related complications (OR=5.0) and prior surgery (OR=3.8) were significantly associated with increased likelihood of pain.
    • No significant gender differences were observed regarding pain, surgery, or HME complications.

    Conclusions:

    • The prevalence of pain in hereditary multiple exostosis has been underestimated.
    • Pain is a substantial clinical problem in HME that requires proactive management strategies.
    • HME-related complications and surgical interventions are key factors contributing to pain in this population.