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Premenstrual asthma.

S K Chhabra1

  • 1Department of Cardiorespiratory Physiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India. skchhabra@mailcity.com

The Indian Journal of Chest Diseases & Allied Sciences
|April 19, 2005
PubMed
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Premenstrual asthma, affecting up to 40% of women with asthma, involves worsening symptoms before menstruation. This review explores its prevalence, mechanisms, and treatment options for this specific asthma phenotype.

Area of Science:

  • Pulmonology
  • Women's Health
  • Endocrinology

Background:

  • Gender disparities exist in asthma prevalence and severity.
  • A distinct phenotype, premenstrual asthma, involves symptom exacerbation linked to the menstrual cycle in women with asthma.

Purpose of the Study:

  • To review the current literature on premenstrual asthma.
  • To understand the prevalence, impact on lung function, and underlying mechanisms of premenstrual asthma.
  • To present available treatment strategies.

Main Methods:

  • Literature review of studies on premenstrual asthma.
  • Analysis of the effect of the menstrual cycle on asthma symptoms and lung function.
  • Discussion of proposed pathogenetic mechanisms, including hormonal influences and airway inflammation.

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Main Results:

  • Premenstrual asthma affects a significant proportion of women with asthma (up to 40%).
  • Menstrual cycle phases demonstrably impact asthma symptom severity and lung function.
  • Hormonal fluctuations and airway inflammation are implicated in the pathogenesis.

Conclusions:

  • Premenstrual asthma is a recognized clinical entity requiring further understanding.
  • Hormonal changes during the menstrual cycle play a crucial role in asthma exacerbations.
  • Targeted treatment approaches for premenstrual asthma are needed.