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Updated: Aug 18, 2026
Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
[Prognostic markers in gastric neuro-endocrine carcinoma]
Maria Sultana Mihailovici1, Luminiţa Ivan, P Plămădeală
1Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi, Facultatea de Medicină, Disciplina Morfopatologie.
Unlabelled:
Gastric endocrine tumors show a wide spectrum of clinical pathologic features. Behaviour prognostic evaluation of these tumors is difficult. The aim of this report is to present a rare case of a neuroendocrine carcinoma with multiple locations in stomach.
Methods:
A 62 years female patient underwent a resection of stomach for a tumor. The paraffin-embedded sections of 12 blocks were studied by histological and immunohistochemical methods including HE, van Gieson, Grimelius, chromogranin A, cytokeratin, neuron-specific enolase, vimentin, desmin, smooth muscle actin, Ki-67 antigen, protein S-100.
Results:
Histological pattern was similar in primary tumor (mucosa and submucosa) and sessile lesion at distance, where it affected only mucosa. Histopathologically, these tumors show a sheet of round to spindle and polyhedral neoplastic cells with hyperchromatic nuclei, considerable mitotic activity. Immunohistochemically, the neoplastic cells were positive for cytokeratin and neuron-specific enolase and a high Ki-67 labelling index. The three lymph nodes from five had metastasis.
Conclusion:
The IHC reactions were needed for diagnosis of multiple neuroendocrine carcinomas with lymph node metastasis. These histological and immunohistochemical criteria were very important for the identification of tumors with the aggressive evolution.