Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tissue microarrays: applications in genomic research.

Aprill Watanabe1, Robert Cornelison, Galen Hostetter

  • 1TMA Core Service, Translational Genomics Research Institute, 400 N. 5 Street, Phoenix AZ 85004, USA.

Expert Review of Molecular Diagnostics
|April 19, 2005
PubMed
Summary

Tissue microarrays (TMAs) offer a versatile technology for cancer research and pathology. This method efficiently analyzes molecular markers, aiding biomarker discovery, validation, and prognostic applications in oncology.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrated proteogenomic and metabolomic profiling of acute myeloid leukemias to identify molecular subtypes and associated therapy targets.

Nature cancer·2026
Same author

<i>UBA1-CDK16</i>: A female-specific chimeric RNA emerging through evolution and involved in immune regulation.

Science advances·2026
Same author

Chronic High-Fat Diet Does Not Alter Overall Cancer Incidence in Trp53R270H/+ Mice.

Cancer research communications·2026
Same author

Plectin promotes an aggressive phenotype and represses cytotoxic T cell activity in pancreatic cancer.

bioRxiv : the preprint server for biology·2026
Same author

A 15-layer multi-omics analysis of gastric cancer ecotypes provides therapeutic insights.

Cell reports. Medicine·2026
Same author

Loss of ZNRF3/RNF43 unleashes EGFR in cancer.

eLife·2026

Area of Science:

  • Oncology
  • Pathology
  • Biotechnology

Background:

  • Tissue microarrays (TMAs) are a widely adopted technology in cancer research and clinical pathology.
  • TMAs enable the precise arrangement of numerous tissue samples for standardized molecular marker analysis.
  • The technology is crucial for biomarker discovery, validation, and quality control in immunohistochemistry.

Purpose of the Study:

  • To review the application and impact of TMAs in cancer research and clinical pathology.
  • To highlight the role of TMAs in biomarker validation, from discovery to prognostic use.
  • To discuss the integration of TMAs with digital imaging and telepathology.

Main Methods:

  • Utilizing high-density TMAs for efficient and standardized analysis of molecular markers.

Related Experiment Videos

  • Applying TMAs in biomarker discovery and validation pipelines, including genome-wide experiments.
  • Employing TMAs for immunohistochemistry quality control and assurance.

    • Main Results:

    • TMAs facilitate the validation of candidate markers identified through methods like complementary DNA expression profiling.
    • A case study illustrates a biomarker's journey from discovery via expression profiling to validation by TMAs and use as a prognostic marker.
    • Digital imaging integration with TMAs enhances research efficiency, enabling automated scoring and remote analysis.

    Conclusions:

    • TMAs are a proven, versatile technology for cancer research, biomarker validation, and clinical pathology.
    • The integration of TMAs with digital imaging offers significant advantages for research and diagnostics.
    • TMAs have broad applications in basic research, prognostic oncology, and drug discovery, supported by both public and private sectors.