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Updated: Aug 18, 2026

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
Published on: September 10, 2014
Molecular diagnostics by microelectronic microchips
Maurizio Ferrari1, Laura Cremonesi, Pierangelo Bonini
1IRCCS Ospedale San Raffaele, Head of the Clinical Molecular Biology & Cytogenetics Laboratory, Diagnostica e Ricerca San Raffaele SPA, and Unit of Genomics for Diagnosis of Human Pathologies, via Olgettina 60, 20132 Milan, Italy. ferrari.maurizio@hsr.it
Abstract:
Molecular diagnostics is being revolutionized by the development of highly advanced technologies for DNA and RNA testing. One of the most important challenges is the integration of microelectronics to microchip-based nucleic acid technologies. The specific characteristics of these microsystems make the miniaturization and automation of any step of a molecular diagnostic procedure possible. This review describes the application of microelectronics to all the processes involved in a genetic test, particularly to sample preparation, DNA amplification and sequence variation detection.
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