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Related Experiment Videos

Chlamydia trachomatis-associated ectopic pregnancy: serologic and histologic correlates.

R C Brunham1, R Peeling, I Maclean

  • 1Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada.

The Journal of Infectious Diseases
|June 1, 1992
PubMed
Summary

Chlamydia trachomatis infection is linked to ectopic pregnancy. This study found higher plasma cell infiltration in fallopian tubes of women with ectopic pregnancies, suggesting a role for Chlamydia trachomatis in its development.

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Area of Science:

  • Reproductive Medicine
  • Infectious Diseases
  • Immunology

Background:

  • Ectopic pregnancy is a significant cause of maternal morbidity.
  • Chlamydia trachomatis is a common sexually transmitted infection with potential reproductive consequences.

Purpose of the Study:

  • To investigate the association between Chlamydia trachomatis infection and ectopic pregnancy.
  • To examine histopathological findings and immune responses in women with ectopic pregnancy.

Main Methods:

  • Histopathological examination of fallopian tubes for plasma cell infiltration.
  • Serological testing for Chlamydia trachomatis antibodies, including to a 57-kDa antigen.
  • Chlamydia trachomatis isolation attempts.

Main Results:

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  • Significantly higher plasma cell infiltration in fallopian tubes of women with ectopic pregnancy compared to tubal ligation controls (65% vs. 33%).
  • Plasma cell infiltration strongly correlated with Chlamydia trachomatis seropositivity in both groups.
  • A high prevalence of antibodies to the Chlamydia trachomatis 57-kDa antigen was observed in seropositive women with ectopic pregnancy.

Conclusions:

  • Chlamydia trachomatis infection is associated with increased plasma cell infiltration in the fallopian tube.
  • Immune responses to the 57-kDa antigen may play a role in the immunopathogenesis of Chlamydia trachomatis-associated ectopic pregnancy.