Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neurogenetics II: complex disorders.

A F Wright1

  • 1MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK. alan.wright@hgu.mrc.ac.uk

Journal of Neurology, Neurosurgery, and Psychiatry
|April 19, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First Report of Lasiodiplodia theobromae Associated with Stem Blight of Southern Highbush Blueberries in Florida.

Plant disease·2019
Same author

Identification of Species in the Botryosphaeriaceae Family Causing Stem Blight on Southern Highbush Blueberry in Florida.

Plant disease·2019
Same author

First Report of Stem Blight of Blueberry in California Caused by Neofusicoccum parvum.

Plant disease·2019
Same author

Regional heritability mapping method helps explain missing heritability of blood lipid traits in isolated populations.

Heredity·2015
Same author

Photoreceptor rescue by an abbreviated human RPGR gene in a murine model of X-linked retinitis pigmentosa.

Gene therapy·2015
Same author

Application of high-dimensional feature selection: evaluation for genomic prediction in man.

Scientific reports·2015
Same journal

Characteristics and outcomes in electric scooter-related traumatic brain injuries in Helsinki.

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Chronological ageing and ovarian reserve in MS: insights from anti-Müllerian hormone and disability progression.

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Durable fluoropolymer drug-eluting stent versus bare-metal stent for the prevention of intracranial in-stent restenosis.

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Correction: <i>How well do plasma Alzheimer's disease biomarkers reflect the CSF amyloid status?</i>

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Correction: <i>First presentation with neuropsychiatric symptoms in autosomal dominant Alzheimer's disease: the Dominantly Inherited Alzheimer's Network Study</i>.

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Correction: <i>Clinical utility of cerebrospinal fluid biomarkers in the evaluation of cognitive impairment: a systematic review and meta-analysis</i>.

Journal of neurology, neurosurgery, and psychiatry·2026
See all related articles

Genetic analysis offers insights into neurological disorders, identifying susceptibility genes and mechanisms. Advanced technologies and models enhance understanding of diseases like Alzheimer's and Parkinson's.

Area of Science:

  • Neurogenetics
  • Molecular Neurology

Background:

  • Genetic analysis is crucial for understanding common neurological disorders, building upon insights from rare inherited subgroups.
  • Identifying susceptibility genes with smaller effects presents challenges but is advancing with new technologies.

Purpose of the Study:

  • To explore the role of genetics and emerging technologies in elucidating the etiology of common neurological disorders.
  • To highlight the potential impact of understanding neural stem cell mechanisms on clinical practice.

Main Methods:

  • Analysis of rare inherited neurological disorder subgroups.
  • Leveraging advanced technologies including neuroimaging, animal models, high-throughput gene chips, expression microarrays, and proteomics.
  • Investigating genetic and epigenetic mechanisms of human neural stem cell differentiation and integration.

Related Experiment Videos

Main Results:

  • Genetics has illuminated the etiology of several major neurological disorders.
  • New technologies are expanding the capabilities of traditional genetic mapping tools.
  • Understanding neural stem cell mechanisms holds significant clinical potential.

Conclusions:

  • Continued genetic analysis, aided by technological advancements, will yield crucial insights into neurological diseases.
  • Interdisciplinary approaches combining genetics, neuroimaging, and stem cell biology are vital for advancing neurological disorder research and clinical practice.