Related Experiment Video
Updated: Feb 16, 2026
Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
Published on: September 22, 2017
Optical coherence tomography characterisation of idiopathic central serous chorioretinopathy
1Instituto Oftalmológico de Alicante, Vitreo-Retinal Unit, Avenida de Denia 111, 03015 Alicante, Spain. msm02va@wanadoo.es
Aim:
To describe retinal findings in patients with idiopathic central serous chorioretinopathy (ICSC) as assessed by optical coherence tomography (OCT), and to compare them to fluorescein angiography (FA) findings.
Methods:
Case series of 39 eyes from 36 patients with ICSC. Complete ophthalmological examination, last generation OCT (StratusOCT, Software version 3.1) and FA were performed. Six radial scans using OCT were performed and repeated. Singular findings were recorded, OCT images were measured and the results compared with those of FA. The main outcome measures were FA and OCT findings.
Results:
Two patterns of distinct OCT findings are described. In the first one, an optically empty vaulted area of different heights was observed under the neurosensory retina in 36 eyes, being related to fluorescein filled areas; in 35 of them, highly characteristic small bulges could be observed protruding from the retinal pigment epithelium (RPE), angiographically related to leaking spots. In the second pattern, three eyes showed an almost semicircular space under the RPE, with thinner overlying retina.
Conclusions:
OCT may offer a new approach to the staging and knowledge of ICSC, and may help the understanding of the mechanisms of the disease.
Related Concept Videos
01:21Trait Centrality
01:25The Central Dogma
01:20The Central Dogma
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
02:16Measures of Central Tendency
01:14What is Central Tendency?
The central tendency is the most conventionally used data characteristic. It is a...
01:10Computed Tomography
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...