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Related Experiment Videos

Percutaneous penetration through slightly damaged skin.

Jesper B Nielsen1

  • 1Environmental Medicine, University of Southern Denmark, Winsløwparken 17, 5000, Odense C, Denmark. jbnielsen@health.sdu.dk

Archives of Dermatological Research
|April 19, 2005
PubMed
Summary

Slightly damaged skin significantly increases chemical penetration, especially for hydrophilic compounds. This finding is crucial for setting accurate dermal exposure standards in occupational and household settings.

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Area of Science:

  • Toxicology
  • Dermatology
  • Occupational Health

Background:

  • Percutaneous penetration studies typically assume optimal skin barrier integrity.
  • Occupational and household skin exposure often involves compromised skin barriers, leading to health issues and work absence.

Purpose of the Study:

  • To evaluate an experimental model for assessing chemical percutaneous penetration through slightly damaged human skin.
  • To investigate the impact of minor skin barrier damage on the penetration of various pesticides.

Main Methods:

  • Human skin explants were used in static diffusion cells.
  • A controlled, slight skin barrier damage was induced using sodium lauryl sulphate (SLS) pre-treatment (0.1% or 0.3%) for 3 hours.
  • Percutaneous penetration of five pesticides with varying solubilities was measured over 48 hours.

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Main Results:

  • SLS pre-treatment induced significant, stable skin barrier damage for 48 hours.
  • Slightly damaged skin significantly altered the rate, lag-time, and total percutaneous penetration of pesticides.
  • The penetration of hydrophilic compounds was most affected by the induced skin damage.

Conclusions:

  • A slightly damaged skin barrier can substantially increase chemical absorption.
  • Hydrophilic chemicals are particularly susceptible to enhanced penetration through compromised skin.
  • These results necessitate re-evaluation of dermal exposure standards for chemicals, considering non-ideal skin conditions.