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Behavioral thermoregulation by hypoxic rats.

R K Dupré1, T L Owen

  • 1Department of Biological Sciences, University of Nevada, Las Vegas 89154.

The Journal of Experimental Zoology
|May 1, 1992
PubMed
Summary
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Hypoxia shifts the hypothalamic thermal setpoint in rats, causing them to seek warmer environments but maintain a lower body temperature (Tb). This behavioral thermoregulation conserves oxygen during low oxygen conditions.

Area of Science:

  • Physiology
  • Neuroscience
  • Environmental Health

Background:

  • Hypoxic hypothermia can be induced by reduced oxygen supply.
  • Thermoregulation plays a critical role in oxygen consumption.

Purpose of the Study:

  • To investigate if a shift in the hypothalamic thermal setpoint contributes to hypoxic hypothermia.
  • To examine the role of behavioral thermoregulation in response to hypoxia.

Main Methods:

  • Behavioral thermoregulation was assessed in Sprague-Dawley rats using radiotelethermometers for deep body temperature (Tb) measurement.
  • Experiments were conducted under normoxia (PO2 = 125 torr) and hypoxia (PO2 = 60 torr) using a thermocline.

Main Results:

  • Under normoxia, rats selected an ambient temperature of 19.7°C and maintained Tb at 37.0°C.

Related Experiment Videos

  • Under hypoxia, rats selected a significantly warmer ambient temperature (28.6°C) but maintained a significantly lower Tb (35.5°C).
  • Even without a thermal gradient, Tb during hypoxia was 35.4°C.

    • Conclusions:

    • The findings support the hypothesis that hypoxia shifts the thermoregulatory setpoint to a lower Tb.
    • This setpoint shift promotes thermoregulation at a reduced Tb, thereby lowering oxygen demand during limited oxygen supply.