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Published on: May 26, 2022
[New guidelines for treatment of hypertension]
1Abteilung Nephrologie, Zentrum Innere Medizin der Medizinischen Hochschulen Hannover. Nephrologie@MH-Hannover.de
Insights
Managing high blood pressure is key to preventing cardiovascular disease. New guidelines emphasize lower blood pressure targets, especially for those with diabetes or kidney disease, recommending specific drug classes for effective treatment.
Area of Science:
- Cardiology
- Nephrology
- Endocrinology
Context:
- Cardiovascular disease prevention relies heavily on effective high blood pressure management.
- Recent hypertension classifications highlight the link between blood pressure levels and cardiovascular risk.
- Individualized treatment goals are set based on existing end-organ damage.
Purpose:
- To outline the updated classification of hypertension and its implications for cardiovascular disease prevention.
- To define target blood pressure levels, considering comorbidities like diabetes and kidney disease.
- To review recommended primary treatment strategies and pharmacologic classes for hypertension.
Summary:
- The updated hypertension classification designates blood pressure between 130/80 and 140/90 mmHg as high-normal, with a general goal of <140/90 mmHg.
- Specific therapeutic targets are 130/80 mmHg for patients with diabetes mellitus and 125/75 mmHg for those with kidney disease and proteinuria.
- Recommended primary treatments include diuretics, beta-blockers, calcium antagonists, ACE inhibitors, and angiotensin receptor blockers, with combination therapy as a viable option.
Impact:
- Provides clinicians with updated guidelines for hypertension management, aiding in cardiovascular risk reduction.
- Emphasizes personalized treatment approaches based on patient-specific factors and comorbidities.
- Highlights the importance of specific drug classes and combination therapies in achieving optimal blood pressure control.
Abstract:
Treatment of high blood pressure is a central element in prevention of cardiovascular diseases. The new classification of hypertension takes into consideration the close association between blood pressure level and cardiovascular risk and designates blood pressure between 140/90 and 130/80 mmHg as high-normal so that blood pressure <140/90 mmHg should always be the goal. The targeted blood pressure levels are also defined by the extent of end-organ damage already present. The therapeutic objective in patients with diabetes mellitus is a blood pressure level of 130/80 mmHg and in patients with kidney disease and proteinuria 125/75 mmHg. The five substance groups of diuretics, beta-blockers, calcium antagonists, ACE inhibitors, and angiotensin receptor blockers are recommended for primary treatment. In addition to the antihypertensive properties, substance-specific effects of ACE inhibitors and angiotensin receptor blockers have been described. Primarily, instead of monotherapy low-dose combination therapy can also be judicious.
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