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Related Experiment Videos

Optic radiation changes after optic neuritis detected by tractography-based group mapping.

Olga Ciccarelli1, Ahmed T Toosy, Simon J Hickman

  • 1Department of Headache, Brain Injury and Neurorehabilitation, Institute of Neurology, University College London, Queen Square, London, United Kingdom.

Human Brain Mapping
|April 19, 2005
PubMed
Summary

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Optic neuritis can cause changes in the optic radiations, visible with diffusion MRI. These findings suggest a potential method for assessing visual pathway damage after optic nerve injury.

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Radiology

Background:

  • Postmortem studies indicate trans-synaptic degeneration in the lateral geniculate nucleus following optic nerve injury.
  • Investigating in vivo changes in the visual pathway after optic nerve damage is crucial for understanding disease progression.

Purpose of the Study:

  • To investigate in vivo changes in the optic radiations in patients with optic neuritis using diffusion MRI.
  • To assess the utility of fast marching tractography (FMT) and group mapping techniques for evaluating optic radiation integrity.

Main Methods:

  • Employed fast marching tractography (FMT), a diffusion MRI technique, for fiber tracking.
  • Utilized group mapping with statistical parametric mapping (SPM99) to compare optic radiations between seven patients with optic neuritis and ten healthy controls.

Related Experiment Videos

  • Generated voxel-scale connectivity (VSC) maps to quantify white matter integrity.

    • Main Results:

    • Patients with optic neuritis showed altered localization of optic radiations, appearing more lateral and inferior posteriorly compared to controls.
    • Reduced VSC values were observed in the optic radiations of patients, indicating decreased white matter integrity.
    • Group mapping techniques successfully highlighted differences in the optic radiations between patients and controls.

    Conclusions:

    • Diffusion MRI with FMT and group mapping can detect in vivo changes in the optic radiations following optic neuritis.
    • Observed alterations in the optic radiations are likely secondary to the initial optic nerve damage.
    • These techniques may offer a valuable tool for assessing visual pathway damage in clinical settings.