Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Subcortical aphasia from a thalamic abscess.

J Megens1, J van Loon, J Goffin

  • 1Department of Neurology and Neurosurgery, University Hospital Gasthuisberg, Leuven, Belgium.

Journal of Neurology, Neurosurgery, and Psychiatry
|April 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immuno-molecular features and therapeutic implications of brain metastases in clear cell renal cell carcinoma patients.

Genes and immunity·2026
Same author

Cost-effectiveness of proton radiotherapy versus photon radiotherapy for non-small cell lung cancer patients: Exploring the model-based approach.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2022
Same author

Ceramic-on-ceramic articulation in press-fit total hip arthroplasty as a potential reason for early failure, what about the survivors: a ten year follow-up.

International orthopaedics·2021
Same author

Impaired Geriatric 8 Score is Associated with Worse Survival after Radiotherapy in Older Patients with Cancer.

Clinical oncology (Royal College of Radiologists (Great Britain))·2020
Same author

Community-acquired bacterial meningitis in adults: emergency department management protocol.

Acta neurologica Belgica·2020
Same author

Dynamic trial fitting by an expanding trial cup does not jeopardize primary acetabular component stability.

Clinical biomechanics (Bristol, Avon)·2020

A thalamic abscess caused subcortical aphasia, but SPECT scans revealed improved language and reduced cortical hypoperfusion after treatment. This suggests secondary cortical dysfunction, potentially explained by cortical diaschisis, may underlie aphasia from subcortical lesions.

Area of Science:

  • Neurology
  • Neuroimaging
  • Infectious Diseases

Background:

  • Subcortical lesions, such as thalamic abscesses, can lead to aphasia, a language disorder.
  • The underlying mechanisms of aphasia secondary to subcortical lesions are not fully understood.
  • Existing evidence primarily links such aphasia to stroke-related lesions.

Observation:

  • A patient with a left thalamic abscess developed subcortical aphasia.
  • Initial SPECT scans showed significant hypoperfusion in the left cerebral cortex.
  • Following successful abscess treatment, the patient exhibited marked improvement in language function and reduced cortical hypoperfusion.

Findings:

  • The case demonstrates that aphasia associated with subcortical lesions can resolve with treatment of the primary lesion.

Related Experiment Videos

  • Improvement in language disorder correlated with resolution of cortical hypoperfusion, suggesting a functional connection.
  • This case supports the hypothesis that aphasia in subcortical lesions results from secondary cortical dysfunction.

    • Implications:

    • The findings challenge the exclusive focus on stroke lesions when considering secondary cortical dysfunction and aphasia.
    • The case provides a potential clinical example supporting the theory of cortical diaschisis as a mechanism for aphasia in this context.
    • Further research into non-stroke related subcortical lesions is warranted to explore pathophysiological mechanisms like cortical diaschisis.