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Updated: Aug 18, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Histological findings in titanium implants coated with calcium phosphate ceramics installed in rabbit's tibias
Fabio Franceschini Mitri1, Marcelo Yoshimoto, Sérgio Allegrini Júnior
1Department of Functional Anatomy, Structure and Ultra-Structure, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 2415, Cidade Universitária 05508-900, São Paulo, SP, Brasil.
Abstract:
Oral reconstruction using osteointegrated implants are widely indicated nowadays. The implant bone anchorage is very important for its functional stability. Thus, ceramic biomaterials are widely used as coatings of the implant surfaces to accelerate local osteogenesis. The purpose of this study is to assess the biocompatibility and the osteoconduction of two types of calcium phosphate ceramics used as titanium dental implant coatings. These implants were installed in rabbit tibia during an 8-week healing period. The light and fluorescent microscopy observations showed that the materials are biocompatible and that they have osteoconductive activities.
