Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The sphincter of Oddi: understanding its control and function.

C M Woods1, G M Mawe, J Toouli

  • 1Pancreatobiliary Research Group, Department of General and Digestive Surgery, Flinders University, Flinders Medical Centre, Bedford Park, Australia.

Neurogastroenterology and Motility
|April 20, 2005
PubMed
Summary

Disordered sphincter of Oddi (SO) motility causes biliary tract and pancreatic issues. Understanding SO function and regulation is key to developing new therapies for SO dysfunction and pancreatitis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Cross validated serum small extracellular vesicle microRNAs for the detection of oropharyngeal squamous cell carcinoma.

Journal of translational medicine·2022
Same author

Cross validated serum small extracellular vesicle microRNAs for the detection of oropharyngeal squamous cell carcinoma.

Journal of translational medicine·2020
Same author

Gut-derived serotonin contributes to bone deficits in colitis.

Pharmacological research·2018
Same author

Altered gastrointestinal motility involving autoantibodies in the experimental autoimmune encephalomyelitis model of multiple sclerosis.

Neurogastroenterology and motility·2018
Same author

Review article: the many potential roles of intestinal serotonin (5-hydroxytryptamine, 5-HT) signalling in inflammatory bowel disease.

Alimentary pharmacology & therapeutics·2017
Same author

Cost analysis of injection laryngoplasty performed under local anaesthesia versus general anaesthesia: an Australian perspective.

The Journal of laryngology and otology·2017

Area of Science:

  • Gastroenterology
  • Physiology
  • Surgical Science

Background:

  • Sphincter of Oddi (SO) dysfunction and acute pancreatitis are common, painful conditions linked to abnormal SO motility.
  • The SO, a neuromuscular structure, regulates bile and pancreatic juice flow into the duodenum and prevents duodenal reflux.

Purpose of the Study:

  • To review current knowledge on the control and regulation of SO motility.
  • To highlight recent laboratory and clinical research (last 5 years) on SO function.

Main Methods:

  • Review of studies on SO function, spontaneous activity control, responses to bioactive agents, innervation, and gastrointestinal reflexes.
  • Synthesis of findings from laboratory-based and clinical research.

Main Results:

Related Experiment Videos

  • Established understanding of normal SO function and its regulation.
  • Identified key factors influencing SO motility, including neural and humoral control.
  • Highlighted research advancements in understanding SO pathophysiology.

Conclusions:

  • Current knowledge provides a foundation for understanding SO-related disorders.
  • Further research into SO motility control may lead to targeted therapeutic strategies for SO dysfunction and acute pancreatitis.