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Related Experiment Videos

Systemic scleroderma: a spatiotemporal clustering.

H Englert1, E Joyner, R Bade

  • 1Rheumatology Department, Westmead Hospital, Westmead, NSW 2145, Australia.

Internal Medicine Journal
|April 20, 2005
PubMed
Summary
This summary is machine-generated.

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A spatiotemporal cluster of systemic scleroderma was identified in Edenhope, Victoria, with a tenfold increased incidence. Environmental factors are suspected, though no single agent was implicated, suggesting potential silica or infective agents.

Area of Science:

  • Epidemiology
  • Environmental Health
  • Rheumatology

Background:

  • The causes of systemic scleroderma are not well understood, with limited evidence for genetic factors.
  • Silica and vinyl chloride monomer exposure are suspected environmental triggers.
  • Previous studies have reported spatiotemporal clustering of systemic scleroderma in only three instances.

Purpose of the Study:

  • To investigate a potential spatiotemporal cluster of systemic scleroderma in Edenhope, western Victoria.
  • To estimate the cumulative incidence and identify potential etiological factors within this cluster.

Main Methods:

  • Prevalence and cumulative incidence data were collected and validated.
  • Age- and gender-matched controls were used for comparison.

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  • A postal questionnaire gathered information on environmental exposures and medical history.

    • Main Results:

    • Six cases of systemic scleroderma and one mixed connective tissue disease case were identified.
    • The 5-year cumulative incidence was significantly higher (6.1/10,000) than expected.
    • No genetic relationship was found between cases, and no single environmental agent was consistently implicated.

    Conclusions:

    • A validated spatiotemporal cluster of systemic scleroderma exists around Edenhope, with a tenfold increased cumulative incidence.
    • The cluster extended beyond the initial 50 km radius, indicating a wider potential exposure.
    • The findings suggest an environmental agent with high frequency but low disease conversion rates, such as silica or an infectious agent, may be responsible.