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Oocyte-expressed genes affecting ovulation rate.

K P McNatty1, P Smith, L G Moore

  • 1AgResearch, Wallaceville Animal Research Centre, P.O. Box 40063, Upper Hutt, New Zealand. ken.mcnatty@agresearch.co.nz

Molecular and Cellular Endocrinology
|April 20, 2005
PubMed
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Mutations in BMP15 and GDF9 genes and the ALK6 receptor increase ovulation rates in sheep. However, homozygous mutations in BMP15 or GDF9 cause sterility by arresting follicular development.

Area of Science:

  • Animal Genetics
  • Reproductive Biology
  • Molecular Endocrinology

Background:

  • Inherited traits influence ovulation rate in sheep.
  • Specific growth factor genes (BMP15, GDF9) and a receptor (ALK6) expressed in oocytes are implicated in ovulation control.

Purpose of the Study:

  • To investigate the impact of mutations in BMP15, GDF9, and ALK6 on ovulation rate and follicular development in sheep.
  • To understand the role of these genes in mammalian fertility regulation.

Main Methods:

  • Examination of inherited patterns of ovulation rate in different sheep breeds.
  • Identification and analysis of point mutations in BMP15, GDF9, and ALK6 genes.
  • Assessment of follicular development and ovarian function in mutant animals.

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Main Results:

  • Five BMP15 mutations, one GDF9 mutation, and one ALK6 mutation were identified.
  • Heterozygous carriers of these mutations exhibited increased ovulation rates (+0.6-10).
  • Homozygous BMP15 or GDF9 mutations led to sterility due to arrested primary follicular growth.
  • ALK6 mutation resulted in precocious follicular maturation and ovulation of multiple smaller follicles.

Conclusions:

  • BMP15, GDF9, and ALK6 play crucial roles in sheep follicular development and ovulation.
  • Mutations in these genes can significantly alter ovulation rates, with potential for both enhancement and sterility.
  • These genes represent potential targets for novel mammalian fertility regulation strategies.