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Updated: Aug 18, 2026

Identification of Potential Anti-TB Candidates: A Step-by-Step Guide to Synthesis, MIC Determination, and Cytotoxicity Assessment in Mammalian Cells
Published on: May 22, 2026
The DOTS strategy for controlling the global tuberculosis epidemic
Thomas R Frieden1, Sonal S Munsiff
1New York City Department of Health and Mental Hygiene, 125 Worth Street, New York, NY 10013, USA. tfrieden@health.nyc.gov
Abstract:
This article reviews the principles, scientific basis, and experience with implementation of the directly observed treatment strategy, short course (DOTS) for tuberculosis. The relevance of DOTS in the context of multidrug-resistant tuberculosis and the HIV epidemic also is discussed.
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