Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Coarse-grained models for proteins.

Valentina Tozzini1

  • 1NEST-INFM Scuola Normale Superiore, Piazza dei Cavalieri 7, I-56126 Pisa, Italy. tozzini@nest.sns.it

Current Opinion in Structural Biology
|April 20, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transient Aggregation-Prone States in Disordered Proteins as Therapeutic Targets: The Amyloid-β Case.

Journal of chemical information and modeling·2026
Same author

Aggregation of Intrinsically Fluorescent Proteins: Combining Coarse-Grained Molecular Dynamics with Alphafold Predictions.

ACS omega·2025
Same author

An intramolecular FRET biosensor for the detection of SARS-CoV-2 in biological fluids.

Nanoscale·2025
Same author

Probing Spatiotemporal Effects of Intertrack Recombination with a New Implementation of Simultaneous Multiple Tracks in TRAX-CHEM.

International journal of molecular sciences·2025
Same author

Editorial: Revolutionizing life sciences: the nobel leap in artificial intelligence-driven biomodeling.

Frontiers in molecular biosciences·2025
Same author

Quantum sensing of microRNAs with nitrogen-vacancy centers in diamond.

Communications chemistry·2024
Same journal

Metabolic disruptions through a three-dimensional genomic lens.

Current opinion in structural biology·2026
Same journal

Collective variable design for biomolecular conformational dynamics.

Current opinion in structural biology·2026
Same journal

Polymer scaling in protein crowding: From dilute coils to semidilute meshes.

Current opinion in structural biology·2026
Same journal

Tuning the physicochemical properties of rationally designed protein-based biomolecular condensates.

Current opinion in structural biology·2026
Same journal

Editorial overview: Folding, binding and protein design.

Current opinion in structural biology·2026
Same journal

Macromolecular crowding reshapes the conformational landscapes of intrinsically disordered proteins: mechanisms, cellular contexts, and functional consequences.

Current opinion in structural biology·2026
See all related articles

Coarse-grained models enable large-scale simulations of biomolecules. Advances in parameterization and algorithms allow direct comparison with advanced spectroscopic techniques, bridging simulation and experiment.

Area of Science:

  • Computational biology
  • Biophysics
  • Molecular modeling

Background:

  • Coarse-grained models are increasingly used for simulating large biomolecular systems.
  • Enhanced computing power allows simulations at biologically relevant scales (sub-micrometric size, microsecond-millisecond timescales).

Purpose of the Study:

  • To highlight recent advances in coarse-grained modeling for proteins and biomolecular aggregates.
  • To discuss the improved accuracy and applicability of these models.

Main Methods:

  • Utilizing coarse-grained representations for proteins and biomolecular aggregates.
  • Employing enhanced computer power for large-scale simulations.
  • Developing rigorous parameterization techniques and novel sampling algorithms.

Related Experiment Videos

Main Results:

  • Simulations now reach biologically relevant sizes and timescales.
  • Noticeable advances in predictive power compared to previous coarse-grained methods.
  • Direct comparison between simulation data and advanced spectroscopic experiments is now feasible.

Conclusions:

  • Coarse-grained models are becoming more powerful and accurate.
  • The convergence of simulation scales and experimental techniques facilitates validation and discovery.
  • These models offer a valuable tool for understanding complex biological systems.