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Updated: Aug 18, 2026

Long-Term Continuous Measurement of Renal Blood Flow in Conscious Rats
Published on: February 8, 2022
[Quantitative evaluation of canine renal blood flow with contrast-enhanced ultrasound]
Wen-Xing Xiao1, Jian-Ping Bin, Jin-Guo Xie
1Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. xwx@fimmu.com
Objective:
To evaluate the accuracy of contrast-enhanced ultrasound (CEU) in renal blood flow quantification.
Methods:
Regional renal perfusion was quantified with CEU in 10 dogs at the baseline level and after treatment with 3 doses of dopamine (3, 8 and 16 mg.kg(-1).min(-1)), and renal arterial flow (RAF) was measured with ultrasonic flow probes deployed directly on the renal artery simultaneously. Normalized RAF was calculated as RAF divided by renal weight (ml.min(-1).g(-1)).
Results:
Compared with the baseline level, a progressive increase in RAF was induced by dopamine treatment at the doses of 3 and 8 mg.kg(-1).min(-1) (P<0.05), but at a higher dose of 16 mg.kg(-1).min(-1), the increment in RAF was reduced in comparison with that with the two lower doses (P<0.05). The same changes in cortical nutrient blood flow derived from CEU were observed. Significant positive correlation was found between normalized RAF and CEU-derived cortical nutrient blood flow (y=39.8x + 44.3, r=0.88, P<0.001).
Conclusion:
CEU can be used to accurately quantify renal blood flow in dogs.
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