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[A case of late-onset Pick's disease with polyuria]
Abstract:
A 72-year-old male was admitted to our hospital with a 2-year history of polyuria, prosopagnosia and aphasia. He showed characteristic clinical features of Pick's disease such as stereotyped verbal output and behavior and personality changes. CT and MRI scans showed marked atrophy in the bilateral anterior temporal lobes mild atrophy of the bilateral frontal lobes. SPECT scans revealed perfusion abnormalities in corresponding areas. A 6-hour-water deprivation test resulted in decrease in the urine volume and in concentration of the urine, suggesting abnormality of his secondary drinking behavior. Polyposia resulting in polyuria as a clinical manifestation may be due to stereotypic behavior which is often seen in Pick's disease.
Insights
This study links Pick's disease to polyuria (frequent urination) and polydipsia (excessive thirst) in a 72-year-old male. Stereotyped behaviors, common in Pick's disease, may explain these urinary and drinking abnormalities.
Area of Science:
- Neuroscience
- Neurology
- Geriatrics
Background:
- Pick's disease is a rare form of frontotemporal dementia.
- It is characterized by behavioral changes, personality shifts, and language impairments.
Observation:
- A 72-year-old male presented with a two-year history of polyuria, prosopagnosia, and aphasia.
- Clinical presentation included stereotyped verbal output, behavior, and personality changes consistent with Pick's disease.
Findings:
- Neuroimaging revealed marked atrophy in the bilateral anterior temporal lobes and mild atrophy in the bilateral frontal lobes.
- SPECT scans demonstrated perfusion abnormalities in the affected brain regions.
- A water deprivation test indicated abnormal secondary drinking behavior, leading to polyuria.
Implications:
- This case suggests a potential link between stereotypic behaviors in Pick's disease and the manifestation of polyuria and polydipsia.
- Understanding this association may aid in diagnosing and managing complex symptoms in patients with frontotemporal dementia.