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Hyperacute diffusion-weighted imaging abnormalities in transient ischemic attack patients signify irreversible
Yuichiro Inatomi1, Kazumi Kimura, Toshiro Yonehara
1Stroke Center, Saiseikai Kumamoto Hospital, Kumamoto, Japan. inatomi@skh.saiseikai.or.jp
Cerebrovascular Diseases (Basel, Switzerland)
|April 20, 2005
Summary
Approximately half of patients with transient ischemic attack (TIA) show diffusion-weighted imaging (DWI) abnormalities in the hyperacute phase. These DWI abnormalities may indicate irreversible brain infarction.
Area of Science:
- Neurology
- Radiology
- Medical Imaging
Background:
- Investigating diffusion-weighted imaging (DWI) abnormalities in the hyperacute phase of transient ischemic attacks (TIAs).
- Characterizing the frequency and clinical features of DWI abnormalities in TIA patients.
Framework:
- Utilizing magnetic resonance imaging (MRI) including DWI, T2-weighted, and fluid attenuation inversion recovery (FLAIR) sequences.
- Comparing hyperacute (within 6 hours) and subacute (2-9 days) phases for lesion detection.
Implementation:
- DWI was performed on 21 TIA patients in both hyperacute and subacute phases.
- Patients were categorized into groups based on the presence (positive) or absence (negative) of hyperacute DWI abnormalities.
Implications:
- Hyperacute DWI abnormalities were observed in approximately 50% of TIA patients.
- These abnormalities persisted into the subacute phase, suggesting irreversibility.
- Hyperacute DWI findings in TIA may signify the presence of brain infarction.