Related Experiment Video
Updated: Aug 18, 2026
Noninvasive In Vivo Small Animal MRI and MRS: Basic Experimental Procedures
Published on: October 20, 2009
[Magnetic resonance tomogography after cryotherapy of long bones in an animal model]
G Winnekendonk1, F Popken, U V Smekal
1Institut und Poliklinik für Radiologische Diagnostik, Klinikum der Universität zu Köln. guido.winnekendonk@t-online.de
Purpose:
To describe the MR findings following cryoablation of long bones.
Materials And Method:
Cryoablation was performed in femoral and tibial bones of 24 sheep under general anesthesia. MRI of the treated and untreated contralateral bones was performed immediately thereafter and at 2, 4 and 6 months after the cryosurgical procedure.
Results:
On the MRI performed immediately after cryotherapy, the lesions showed low signal intensities relative to the normal bone marrow on unenhanced T1- and T2-weighted images. At 2, 4 and 6 months after cryoablation, the lesions showed high signal intensities on STIR images, low signal intensities on T1-weighted and heterogeneous enhancement on contrast-enhanced T1-weighted MR images. The femoral lesions decreased in size from 31 +/- 3 mm immediately after the cryotherapy to 13 +/- 4 mm 6 month later and the tibial lesions from 29 +/- 7 mm to 19 +/- 4 mm.
Conclusion:
MRI shows bone marrow lesions immediately after cryotherapy and can easily monitor healing lesions. MR imaging is suitable for following cryotherapy.
