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Age-related changes in serotonin-immunoreactive neurons in the rat nucleus raphe dorsalis and nucleus centralis
1Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
Mechanisms of Ageing and Development
|March 1, 1992
Abstract:
Comparison of serotonin-immunoreactive (SER-IR) neurons in the nucleus raphe dorsalis (NRD) and the nucleus centralis superior (NCS) of 3-month-old and 28-month-old rats was made using qualitative and quantitative immunohistochemical analysis. Significant age-related changes in size and density of the SER-IR somata as well as in the length and number of their processes were demonstrated. A different vulnerability of the SER-IR neurons in both raphe nuclei to aging was observed that may be related to their different structural and functional features.