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Cutaneous relapse in Hodgkin's disease: a case report
Shyama Jain1, Sonu Nigam, Neeta Kumar
1Department of Pathology, Maulana Azad Medical College and Associated Hospitals, New Delhi, India. jainshyama@rediffmail.com
Acta Cytologica
|April 21, 2005
Summary
Cutaneous Hodgkin's lymphoma, a rare skin manifestation, can present as nodular lesions. Early cytologic diagnosis from skin smears is crucial for timely treatment, even with prior disease history.
Area of Science:
- Oncology
- Dermatology
- Cytopathology
Background:
- Skin involvement in Hodgkin's disease is uncommon.
- It typically signifies advanced disease and a poorer prognosis.
- Cutaneous manifestations can be the first sign of recurrence or progression.
Observation:
- A young male presented with chest wall nodules and cervical lymphadenopathy.
- Cytologic examination of skin lesions revealed atypical mononuclear cells.
- Lymph node aspirates showed classical Reed-Sternberg cells.
Findings:
- The cytologic findings were consistent with Hodgkin's lymphoma.
- A skin biopsy confirmed the diagnosis of cutaneous Hodgkin's disease.
- The patient had a history of treated Hodgkin's disease with prior loss to follow-up.
Implications:
- Cytologic evaluation of skin lesions is vital for diagnosing cutaneous Hodgkin's disease.
- A high index of suspicion is necessary, especially in patients with a history of lymphoma.
- Prompt diagnosis and management can improve patient outcomes.