Related Experiment Video
Updated: Aug 10, 2026
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Chronic migraine and medication-overuse headache through the ages
1Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. boes.christopher@mayo.edu
Cephalalgia : an International Journal of Headache
|April 21, 2005
Summary
Chronic migraine has been described for centuries, while medication-overuse headache has been documented for decades. Early researchers like Graham, Friedman, and Lippman pioneered withdrawal protocols for these conditions.
Area of Science:
- Neurology
- Medical History
Background:
- The International Headache Society (IHS) has recently established criteria for chronic migraine and medication-overuse headache.
- Chronic migraine was notably absent from the 1988 IHS criteria, highlighting the evolution of diagnostic understanding.
Observation:
- Early descriptions of chronic migraine date back to Willis (1672), Oppenheim (1900), and others.
- Ergotamine-overuse headache was first described by Peters and Horton in 1951, with broader recognition of acute medication overuse emerging in the 1980s.
- Key figures like Graham, Friedman, and Lippman published early ergotamine withdrawal protocols in the mid-20th century.
Findings:
- This review traces the historical literature on chronic migraine and medication-overuse headache.
- Chronic migraine has a long documented history, appearing in medical literature for centuries.
- Medication-overuse headache has been a subject of medical literature for decades, with early recognition of ergotamine overuse.
Implications:
- Understanding the historical context of chronic migraine and medication-overuse headache is crucial for current diagnostic and treatment strategies.
- The historical review underscores the progressive understanding and classification of these headache disorders.
- Recognizing the early contributions to withdrawal protocols informs contemporary clinical practice for managing medication-overuse headache.
Related Concept Videos
01:02Prescription, Nonprescription and Orphan Drugs
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
01:25Analgesia and Pain Management
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
01:20Opioid Analgesics: Morphine and Other Natural Cogeners
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
01:30Toxidromes: Clinical Features
Toxidromes are specific patterns of symptoms resulting from toxic substance exposure. They help in the identification and treatment of poisoning. The symptoms of each toxidrome group indicate poisoning by a certain class of chemicals or drugs.1. Sympathomimetic: Stimulates the sympathetic nervous system. Symptoms include agitation, increased heart rate (HR), blood pressure (BP), respiratory rate (RR), temperature, and pupil size. Drugs like cocaine and amphetamines, along with tremors and...
01:14Increased Intracranial Pressure l: Introduction
Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...