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Related Experiment Videos

Human hair shape is programmed from the bulb.

S Thibaut1, O Gaillard, P Bouhanna

  • 1L'OREAL Recherche, 14 rue Théodore de Banville, 75017 Paris, France.

The British Journal of Dermatology
|April 21, 2005
PubMed
Summary
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Hair curliness originates in the hair follicle bulb, driven by asymmetrical cell differentiation. This study investigated the unique growth and morphology of curly hair follicles.

Area of Science:

  • Dermatology
  • Hair Biology
  • Cellular Morphology

Background:

  • Limited biological data exists for curly hair follicles.
  • Understanding curly hair follicle biology is crucial for hair research.

Purpose of the Study:

  • To investigate the growth and morphology of curly hair follicles.
  • To elucidate the biological basis of hair curliness.

Main Methods:

  • Dissection of scalp skin follicles from diverse ethnic groups (African, Guyanese, Caucasian).
  • Macroscopic observation, in vitro culture (William's E medium), and immunohistochemistry.
  • Analysis of follicle implantation, bulb shape, sheath symmetry, and cell proliferation (Ki-67).

Main Results:

Related Experiment Videos

  • Curly hair follicles exhibit a curved dermal implantation and a bent bulb, unlike straight Caucasian follicles.
  • In vitro growth showed maintained curvature in the hair shaft; proliferation was asymmetrical, with delayed differentiation on the convex side.
  • Outer root sheath (ORS) cells expressed alpha-smooth muscle actin on the concave side, indicating mechanical stress.

    • Conclusions:

    • Hair curliness is intrinsically programmed within the hair follicle bulb.
    • Asymmetry in differentiation programs is a key factor in determining hair curl.