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Promoter polymorphism of second tryptophan hydroxylase isoform (TPH2) in schizophrenia and suicidality
Vincenzo De Luca1, Daphne Voineskos, Gregory W H Wong
1Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Street, R-30, Toronto, Ontario, Canada M5T 1R8. Vincenzo_Deluca@camh.net
Abstract:
Allele and haplotype frequencies of a promoter polymorphism in the gene encoding tryptophan hydroxylase (TPH2) did not differ in 83 suicidal schizophrenic patients compared with 170 non-suicidal schizophrenic patients. These findings suggest that these 5' marker haplotypes in the TPH2 gene do not influence suicidal behavior in schizophrenia.
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