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The efficacy of diazepam in enhancing motor function in children with spastic cerebral palsy
Anna Mathew1, M C Mathew, Molly Thomas
1Developmental Paediatrics Unit, Christian Medical College & Hospital, Vellore 632004, Tamil Nadu, India. ashirvad@cmcvellore.ac.in
Insights
Low-dose diazepam effectively reduces muscle spasm and improves movement in children with spastic cerebral palsy. This safe and affordable treatment enhances physical therapy and mobility without causing drowsiness.
Area of Science:
- Neurology
- Pediatrics
- Pharmacology
Background:
- Spastic cerebral palsy (CP) is characterized by muscle spasm and hypertonia, significantly limiting mobility in affected children.
- Effective management strategies are crucial for improving motor function and quality of life in pediatric CP patients.
Purpose of the Study:
- To evaluate the clinical efficacy of low-dose diazepam in improving movement and reducing spasticity in children with spastic cerebral palsy.
- To assess the safety profile, specifically daytime drowsiness, associated with diazepam use in this population.
Main Methods:
- A double-blind, placebo-controlled, randomized clinical trial involving 180 children with spastic cerebral palsy.
- Participants were randomly assigned to receive either low-dose diazepam or a placebo at bedtime.
- 173 children completed the study, with outcomes assessed for efficacy and safety.
Main Results:
- Diazepam administration resulted in a significant reduction in hypertonia (muscle stiffness).
- Improvements were observed in the range of passive movement and an increase in spontaneous movements.
- No instances of daytime drowsiness were reported among the participants receiving diazepam.
Conclusions:
- Low-dose diazepam is an effective and safe therapeutic option for managing spasticity and enhancing mobility in children with spastic cerebral palsy.
- Given its low cost, diazepam presents a viable treatment option, particularly in developing countries, to support physical therapy and improve motor function.
Abstract:
Muscle spasm and hypertonia limit mobility in children with spastic cerebral palsy. This double-blind, placebo-controlled, randomized controlled clinical trial studies the clinical efficacy of a low dose of diazepam in enhancing movement in children with spastic cerebral palsy. One hundred and eighty children fulfilled the criteria and were randomly allocated to receive one of two doses of diazepam or placebo at bedtime; 173 completed the study. There was a significant reduction of hypertonia, improvement in the range of passive movement, and an increase in spontaneous movement in the children who received diazepam. There was no report of daytime drowsiness. In developing countries, where cost factors often determine choice of drug, diazepam is a cheap and effective way of relieving spasm and stiffness, optimizing physical therapy and facilitating movement in children with spasticity.
